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Pineal gland

 

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Pineal gland
Illu pituitary pineal glands.jpg
Diagram of pituitary and pineal glands in the human brain
Details
PrecursorNeural ectoderm, roof of diencephalon
Arteryposterior cerebral artery
Identifiers
Latinglandula pinealis
MeSHPineal+gland
NeuroLex IDPineal body
TAA11.2.00.001
FMA62033
Anatomical terms of neuroanatomy
Pineal gland or epiphysis (in red in back of the brain). Expand the image to an animated version
The pineal gland, also known as the pineal body, conarium or epiphysis cerebri, is a small endocrine gland in the vertebrate brain. The shape of the gland resembles a pine cone, hence its name. The pineal gland is located in the epithalamus, near the center of the brain, between the two hemispheres, tucked in a groove where the two halves of the thalamus join. The pineal gland produces melatonin, a serotonin derived hormone which modulates sleep patterns in both circadian and seasonal cycles.[1][2]
Nearly all vertebrate species possess a pineal gland. The most important exception is the hagfish, which is often thought of as the most primitive extant vertebrate.[3] Even in the hagfish, however, there may be a "pineal equivalent" structure in the dorsal diencephalon.[4] The lancelet Branchiostoma lanceolatum, the nearest existing relative to vertebrates, also lacks a recognizable pineal gland.[3] The lamprey (considered almost as primitive as the hagfish), however, does possess one.[3] A few more developed vertebrates lost pineal glands over the course of their evolution.[5]
The results of various scientific research in evolutionary biology, comparative neuroanatomy and neurophysiology, have explained the phylogeny of the pineal gland in different vertebrate species. From the point of view of biological evolution, the pineal gland represents a kind of atrophied photoreceptor. In the epithalamus of some species of amphibians and reptiles, it is linked to a vestigial organ, known as the parietal eye which is also called the third eye.[6]
René Descartes believed the pineal gland to be the "principal seat of the soul". Academic philosophy among his contemporaries considered the pineal gland as a neuroanatomical structure without special metaphysical qualities; science studied it as one endocrine gland among many. However, the pineal gland continues to have an exalted status in the realm of pseudoscience.[7]


Structure[edit]

The pineal gland is the only midline brain structure that is unpaired (azygous). It takes its name from its pine-cone shape.[8] The gland is reddish-gray and about the size of a grain of rice (5–8 mm) in humans. The pineal gland, also called the pineal body, is part of the epithalamus, and lies between the laterally positioned thalamic bodies and behind the habenular commissure. It is located in the quadrigeminal cistern near to the corpora quadrigemina.[9] It is also located behind the third ventricle and is bathed in cerebrospinal fluid supplied through a small pineal recess of the third ventricle which projects into the stalk of the gland.[10]

Blood supply[edit]

Unlike most of the mammalian brain, the pineal gland is not isolated from the body by the blood–brain barrier system;[11] it has profuse blood flow, second only to the kidney,[12] supplied from the choroidal branches of the posterior cerebral artery.

Innervation[edit]

The pineal gland receives a sympathetic innervation from the superior cervical ganglion. A parasympathetic innervation from the pterygopalatine and otic ganglia is also present.[13] Further, some nerve fibers penetrate into the pineal gland via the pineal stalk (central innervation). Also, neurons in the trigeminal ganglion innervate the gland with nerve fibers containing the neuropeptide PACAP.

Histology[edit]

Pineal gland parenchyma with calcifications.
Micrograph of a normal pineal gland – very high magnification.
Micrograph of a normal pineal gland – intermediate magnification.
The pineal body consists in humans of a lobular parenchyma of pinealocytes surrounded by connective tissue spaces. The gland's surface is covered by a pial capsule.
The pineal gland consists mainly of pinealocytes, but four other cell types have been identified. As it is quite cellular (in relation to the cortex and white matter), it may be mistaken for a neoplasm.[14]
Cell typeDescription
PinealocytesThe pinealocytes consist of a cell body with 4–6 processes emerging. They produce and secrete melatonin. The pinealocytes can be stained by special silver impregnation methods. Their cytoplasm is lightly basophilic. With special stains, pinealocytes exhibit lengthy, branched cytoplasmic processes that extend to the connective septa and its blood vessels.
Interstitial cellsInterstitial cells are located between the pinealocytes. They have elongated nuclei and a cytoplasm that is stained darker than that of the pinealocytes.
Perivascular phagocyteMany capillaries are present in the gland, and perivascular phagocytes are located close to these blood vessels. The perivascular phagocytes are antigen presenting cells.
Pineal neuronsIn higher vertebrates neurons are usually located in the pineal gland. However, this is not the case in rodents.
Peptidergic neuron-like cellsIn some species, neuronal-like peptidergic cells are present. These cells might have a paracrine regulatory function.
In some parts of the brain and in particular the pineal gland, there are calcium structures, the number of which increases with age, called corpora arenacea (or "acervuli," or "brain sand"). Chemical analysis shows that they are composed of calcium phosphate, calcium carbonate, magnesium phosphate, and ammonium phosphate.[15] In 2002, deposits of the calcite form of calcium carbonate were described.[16] Calcium and phosphorus[17] deposits in the pineal gland have been linked with aging.

Development[edit]

The human pineal gland grows in size until about 1–2 years of age, remaining stable thereafter,[18][19] although its weight increases gradually from puberty onwards.[20][21] The abundant melatonin levels in children are believed to inhibit sexual development, and pineal tumors have been linked with precocious puberty. When puberty arrives, melatonin production is reduced.[citation needed]

Function[edit]

The primary function of the pineal gland is to produce melatonin. Melatonin has various functions in the central nervous system, the most important of which is to help modulate sleep patterns. Melatonin production is stimulated by darkness and inhibited by light.[22][23] Light sensitive nerve cells in the retina detect light and send this signal to the suprachiasmatic nucleus (SCN), synchronizing the SCN to the day-night cycle. Nerve fibers then relay the daylight information from the SCN to the paraventricular nuclei (PVN), then to the spinal cord and via the sympathetic system to superior cervical ganglia (SCG), and from there into the pineal gland.
The compound pinoline is also claimed to be produced in the pineal gland; it is one of the beta-carbolines.[24] This claim is subject to some controversy.

Regulation of the pituitary gland[edit]

Studies on rodents suggest that the pineal gland influences the pituitary gland's secretion of the sex hormones, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). In a study by Motta, Fraschini, and Martini (1967), a pinealectomy was performed on rodents. No change in pituitary weight was observed, however there was an increase in the concentration of FSH and LH within the gland. In this same study, administration of melatonin did not return the concentrations of FSH to normal levels, suggesting that the pineal gland influences the pituitary glands secretion of FSH and LH through some other transmitting molecule.[25]

Drug metabolism[edit]

Studies on rodents suggest that the pineal gland may influence the actions of recreational drugs, such as cocaine,[26] and antidepressants, such as fluoxetine (Prozac),[27] and that its hormone melatonin can protect against neurodegeneration.[28]

Clinical significance[edit]

Calcification[edit]

Calcification of the pineal gland is typical (1% of study participants) in young adults, and has been observed in children as young as two years of age.[29] The calcified gland is often seen in skull X-Rays.[29] Calcification rates vary widely by country and correlate with an increase in age, with calcification occurring in an estimated 40% of Americans by their 17th year.[29] Calcification of the pineal gland is largely associated with corpora arenacea also known as "brain sand".
It seems that the internal secretions of the pineal gland inhibit the development of the reproductive glands, because, in cases where it is severely damaged in children, the result is accelerated development of the sexual organs and the skeleton.[30]
Some studies show that the degree of pineal gland calcification is significantly higher in patients with Alzheimer's disease vs. other types of dementia.[31]
Pineal gland calcification may also contribute to the pathogenesis of Alzheimer's disease and may reflect an absence of crystallization inhibitors.[31]
Calcium, phosphorus,[17] and fluoride deposits in the pineal gland have been correlated with aging, showing that, as the brain ages, more deposits collect.[32] By old age, the pineal gland contains about the same amount of fluoride as teeth.[32] Pineal fluoride and pineal calcium are correlated.[32]

Tumours[edit]

Tumours of the pineal gland are called pinealomas. These tumours are rare and 50% to 70% are germinomas that arise from sequestered embryonic germ cells. Histologically they are similar to testicular seminomas and ovarian dysgerminomas.[33]
A pineal tumour can compress the superior colliculi and pretectal area of the dorsal midbrain, producing Parinaud's syndrome. Pineal tumours also can cause compression of the cerebral aqueduct, resulting in a noncommunicating hydrocephalus. Other manifestations are the consequence of their pressure effects and consist of visual disturbances, headache, mental deterioration, and sometimes dementia-like behaviour.[34]
These neoplasms are divided into three categories, pineoblastomas, pineocytomas, and mixed tumours, based on their level of differentiation, which, in turn, correlates with their neoplastic aggressiveness.[35] The clinical course of patients with pineocytomas is prolonged, averaging up to several years.[36] The position of these tumours makes them very difficult or impossible to remove surgically.

Other animals[edit]

Pinealocytes in many non-mammalian vertebrates have a strong resemblance to the photoreceptor cells of the eye. Some evolutionary biologists believe that the vertebrate pineal cells possess a common evolutionary ancestor with retinal cells.[37]
Pineal cytostructure seems to have evolutionary similarities to the retinal cells of chordates.[37] Modern birds and reptiles have been found to express the phototransducing pigment melanopsin in the pineal gland. Avian pineal glands are believed to act like the suprachiasmatic nucleus in mammals.[38]
In some vertebrates, exposure to light can set off a chain reaction of enzymatic events within the pineal gland that regulate circadian rhythms.[39] Some early vertebrate fossil skulls have a pineal foramen (opening). This correlates with the physiology of the modern "living fossils," the lampreys and the tuatara, and some other vertebrates that have a parietal eye, which, in some of them, is photosensitive. The parietal eye represents evolution's earlier approach to photoreception.[40] The structures of the pineal eye in the tuatara are analogous to the cornea, lens, and retina, though the latter resembles that of an octopus rather than a vertebrate retina. The asymmetrical whole consists of the "eye" to the left and the pineal sac to the right. "In animals that have lost the parietal eye, including mammals, the pineal sac is retained and condensed into the form of the pineal gland."[40]
Fossils seldom preserve soft anatomy. The brain of the Russian Melovatka bird, about 90 million years old, is an exception, and it shows a larger-than-expected parietal eye and pineal gland.[41]
In humans and other mammals, the light signals necessary to set circadian rhythms are sent from the eye through the retinohypothalamic system to the suprachiasmatic nuclei (SCN) and the pineal gland.

Society and culture[edit]

Diagram of the operation of the pineal gland for Descartes in the Treatise of Man (figure published in the edition of 1664)
Seventeenth-century philosopher and scientist René Descartes was highly interested in anatomy and physiology. He discussed the pineal gland both in his first book, the Treatise of Man (written before 1637, but only published posthumously 1662/1664), and in his last book, The Passions of the Soul (1649) and he regarded it as "the principal seat of the soul and the place in which all our thoughts are formed."[7] In the Treatise of Man, Descartes described conceptual models of man, namely creatures created by God, which consist of two ingredients, a body and a soul.[7][42] In the Passions, Descartes split man up into a body and a soul and emphasized that the soul is joined to the whole body by "a certain very small gland situated in the middle of the brain's substance and suspended above the passage through which the spirits in the brain's anterior cavities communicate with those in its posterior cavities". Descartes attached significance to the gland because he believed it to be the only section of the brain to exist as a single part rather than one-half of a pair. Most of Descartes' basic anatomical and physiological assumptions were totally mistaken, not only by modern standards, but also in light of what was already known in his time.[7][43]
The notion of a "pineal-eye" is central to the philosophy of the French writer Georges Bataille, which is analyzed at length by literary scholar Denis Hollier in his study Against Architecture. In this work Hollier discusses how Bataille uses the concept of a "pineal-eye" as a reference to a blind-spot in Western rationality, and an organ of excess and delirium.[44] This conceptual device is explicit in his surrealist texts, The Jesuve and The Pineal Eye.[45]
In the late 19th century Madame Blavatsky (who founded theosophy) identified the pineal gland with the Hindu concept of the third eye, or the Ajna chakra. This association is still popular today.[7]
Author and researcher Rick Strassman has theorised that the human pineal gland is capable of producing the hallucinogen N,N-dimethyltryptamine (DMT) under certain circumstances.[citation needed] In 2013 he and other researchers first reported DMT in the pineal gland microdialysate of rodents.[46]

History[edit]

The secretory activity of the pineal gland is only partially understood. Its location deep in the brain suggested to philosophers throughout history that it possesses particular importance. This combination led to its being regarded as a "mystery" gland with mystical, metaphysical, and occult theories surrounding its perceived functions.
The pineal gland was originally believed to be a "vestigial remnant" of a larger organ. In 1917, it was known that extract of cow pineals lightened frog skin. Dermatology professor Aaron B. Lerner and colleagues at Yale University, hoping that a substance from the pineal might be useful in treating skin diseases, isolated and named the hormone melatonin in 1958.[47] The substance did not prove to be helpful as intended, but its discovery helped solve several mysteries such as why removing the rat's pineal accelerated ovary growth, why keeping rats in constant light decreased the weight of their pineals, and why pinealectomy and constant light affect ovary growth to an equal extent; this knowledge gave a boost to the then new field of chronobiology.[48]

See also[edit]

Additional images[edit]

The pineal body is labeled in these images.
  • Mesal aspect of a brain sectioned in the median sagittal plane.
  • Dissection showing the ventricles of the brain.
  • Hind- and mid-brains; antero-lateral view.
  • Median sagittal section of brain.
  • Pineal gland
  • Brainstem. Posterior view.

References[edit]

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External links[edit]

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